Download Vorlesungen über Differenzenrechnung by Niels Erik Nörlund (auth.) PDF

By Niels Erik Nörlund (auth.)

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Gay CV, Zheng B, Gilman VR 2003. Co-detection of PTH/PTHrP receptor and tartrate resistant acid phosphatase in osteoclasts. J Cell Biochem 89:902–8. 10. Teitelbaum SL 2000. Bone resorption by osteoclasts. Science 289:1504–8. 11. Dobnig H, Turner RT 1995. Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining cells. Endocrinology 136:3632–8. 12. Hodsman AB, Fraher LJ, Ostbye T, Adachi JD, Steer BM 1993. An evaluation of several biochemical markers for bone formation and resorption in a protocol utilizing cyclical parathyroid hormone and calcitonin therapy for osteoporosis.

58. Wingender E, Chen X, Fricke E, Geffers R, Hehl R, Liebich I, Krull M, Matys V, Michael H, Ohnhauser R, Pruss M, Schacherer F, Thiele S, Urbach S 2001. The TRANSFAC system on gene expression regulation. Nucleic Acids Res 29:281–3. 59. Wingender E, Chen X, Hehl R, Karas H, Liebich I, Matys V, Meinhardt T, Pruss M, Reuter I, Schacherer F 2000. TRANSFAC: an integrated system for gene expression regulation. Nucleic Acids Res 28:316–9. 60. Prestridge DS 1996. 0: additional databases and sequence formats.

The transcript mapping approach (finding TSS by aligning full-length mRNA with their counterpart genomic sequence) described above usually achieves over 80% accuracy in promoter localization (66–68). The incompleteness of full-length transcripts and 5 end splice variants are the main reasons for the false-positive results. This will be improved by future advances in gene annotation. Second, although a PWM-based search is sensitive, it is not very specific because not every putative TFBS binds with its corresponding transcription factor in vivo and is, therefore, functionally significant.

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