By K. D. Gardner Jr (auth.), Kenneth D. Gardner Jr., Jay Bernstein (eds.)
This is a ebook approximately renal cysts and cystic kidneys. Its participants have created a source of present info in a box that after aroused basically interest, yet that now stands on the innovative of molecular nephrology. Its authorship comprises 'oldtimers', who carry the knowledge of expertise, and 'newcomers', whose presence attests to the contributions made via the investigative and technological advances of the prior decade. Its textual content is prepared to hold the reader from renal cyst to cystic renal sickness. each one of its chapters defines or explores a problem or an increase. Cells that line renal cysts are varied in constitution, style, and maybe functionality. The cysts themselves lie inside an interstitium that's not general and will impression cyst improvement and development. Experimental analogs of human disorder supply expanding possibilities to easy researchers to envision, in series and lower than managed conditions, these occasions that prefer nephron dilation, cyst progress and supreme renal failure.
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Extra resources for The Cystic Kidney
1D). 3A-F. Epithelial hyperplasia in the early-stage ADPKD kidney. (A) Low magnification scanning electron micrograph showing a cyst that is lined by cord-like folds of epithelium characteristic of one form of irregular hyperplasia. (Bar = 50 micrometres). (B) This micrograph shows the same cyst seen in Fig. lA, but at a higher magnification. The numerous cord-like folds are lined by cells that are fusiform in shape. These cells do not resemble any normal tubular cell type. 25 micrometres). (C) Areas of irregular hyperplasia are commonly seen in cysts from the early-stage ADPKD kidney.
Lambert PP. Polycystic diseases of the kidney. Archives of Pathology 1947, 44, 34-58. 33. Le J and Vilcek J. Biology of disease: Tumor necrosis factor and interleukin 1: Cytokines with multiple overlapping biological activities. Laboratory Investigation 1987, 56,234--248. 34. Milutinivic J and Agodoa L Y. Potential causes and pathogenesis in autosomal dominant polycystic kidney disease. Nephron 1983, 33, 139-144. 35. Norris RF and Herman L. The pathogenesis of polycystic kidneys: Reconstruction of cystic elements in four cases.
Structure in relation to function Little is known about the function of the renal cyst wall. An important question is whether cysts actively function to modify their fluid content and thereby influence fluid accumulation and cyst growth. Analyses of cyst fluid suggests that some walls possess ion transport activity and retain functional attributes reflecting their tubular origin. Proximal cysts have higher Na + and Cl- and lower creatinine, K +, and H + concentrations than do distal cysts, whereas distal cysts maintain steep concentration gradients for K +, CI-, and creatinine 12,20,30 .