By Shuji Terai, Snorri S. Thorgeirsson (auth.), Kiwamu Okita M.D., Ph.D. (eds.)
Since the first Yamaguchi Symposium on Liver illnesses in 1989, this sequence of symposia has supplied possibilities for exchanges of data at the subject among top jap hepatologists and the world over well known scientists. a little strangely for conferences held in Japan, the reputable language of the symposium is English. the professional ceedings of those symposia are released lower than the identify Frontiers in Hepatology and dispensed world wide. The twelfth symposium used to be hung on December nine and 10,2000, on the ANA inn, Ube, Japan. The subject chosen via the Organizing Committee was once "Growth, Proliferation, and Apoptosis in Hepatocytes;' every one of that's very important within the figuring out of the pathophysiology of intractable liver disorder. 9 jap hepatologists have been invited to offer shows, as used to be best u.S. researcher Professor D.A. Brenner, lately elected editor-in-chief of the magazine Gastroenterology. The stories given on the two-day assembly have been precious in furthering our lower than status of the advanced signaling method thinking about hepatocyte differentiation, proliferation, and apoptosis. growth during this box is quick, and one other symposium at the related subject matter might be held within the close to destiny. We think that those complaints are important in summarizing present info in this very important subject. The Organizing Committee want to convey targeted due to all members and to the Viral Hepatitis study beginning of Japan for its carrying on with monetary support.
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Because the 1st Yamaguchi Symposium on Liver illnesses in 1989, this sequence of symposia has supplied possibilities for exchanges of data at the subject among prime eastern hepatologists and the world over well known scientists. a little bit strangely for conferences held in Japan, the legitimate language of the symposium is English.
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Extra info for Growth, Proliferation, and Apoptosis in Hepatocytes
NO, the product of iNOS, has been implicated as a protective factor or as an apoptotic factor in different cell types. We speculate that iNOS may be one NF-KB-responsive gene that protects from TNF-amediated apoptosis in hepatocytes. We demonstrated that the NO donor, SNAP, inhibits TNF-a- and Fas-mediated apoptosis in IKB-sensitized mouse hepatocytes. Thus, pharmacological doses of NO are sufficient to prevent apoptosis. On the other hand, the NOS inhibitor ~ monomethyl-L-arginine (L-NMMA) sensitizes mouse hepatocytes to TNF-a- and Fasmediated apoptosis even in the absence of blocking NF-KB.
Key words. Signal transduction, MAPK, Cell cycle, HCC, p211WAFl Introduction The majority of the cells in an adult are considered to be in a resting, or quiescent, state. When suitable extracellular cues are present, for example, during a response to injury or surgical resection, cells leave the quiescent state (Go phase) and enter the G) 1 Molecular Therapeutics and 2 Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan 41 42 Y.
RXRa, a retinoid nuclear receptor, is posttranslationally modified by phosphorylation in cancer cells, leading to a loss of its transactivating activity. Failure in inducing its downstream genes that regulate cellular proliferation and apoptosis, such as tissue transglutaminase, may lead the cells to uncontrolled growth. MAP, mitogenactivated protein in HCC tissue . On the other hand, RXR-a is reported to bind to the enhancer element of hepatitis B virus and modulate viral replication .