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By Thomas Hünig, Anneliese Schimpl (auth.), Scott K. Durum, Kathrin Muegge (eds.)

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Hunig and Schimpf 2 gene, in Transgenesis and Targeted Mutagenesis in Immunology (Bluethmann, H. ), Academic, San Diego, CA, pp. 191-201. , and Hunig, T. (1994) Thymic selection and peripheral activation ofTCR-transgenic CDS Tcells in IL-2 deficient mice: requirement for IL-2 is restricted to the induction of cytotoxic effector function. Eur. J. Immunol. 24, 2317-2322. , and Sugamura, K. (1995) Differences in the interleukin-2 (IL-2) receptor system in human and mouse: a chain is required for formation of the functional mouse IL-2 receptor.

Immunol. 24, 281-284. , and Muller, W. (1993) Interleukin-10-deficient mice develop chronic enterocolitis. Cell15, 263-274. , Grusby, M. , Glimcher, L. , Bhan, A. , and Tonegawa, S. (1993) Spontaneous development of inflammatory bowel disease in T-cell receptor mutant mice. Cell15, 275-282. , and Horak, I. (1995) T cells, but not B cells, are required for bowel inflammation in IL-2 deficient mice. J. Exp. Med. 182, 1567-1572. , and Hunig, T. (1995) Immunopathology of Interleukin (IL) 2-deficient mice: thymus dependence and suppression by thymus-dependent cells with an intact IL-2 gene.

Hollander, G. , and Reiser, H. (1996) Activation of CD4+ T lymphocytes from interleukin 2-deficient mice by costimulatory B7 molecules. Proc. Nat/. Acad. Sci. USA 93, 2903-2908. Chapter 2 IL-7 Knockout Mice and the Generation of Lymphocytes Ursula von Freeden-}effry, Thomas A. Moore, Albert Zlotnik, and Richard Murray Introduction A common theme in the molecular interaction between cytokines and their receptors is that an individual cytokine binds a receptor complex. In general, this requires a cytokine-specific receptor subunit and a "common" receptor subunit.

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