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The centrifuges shown here separate the components of the microorganisms, and then further separation is carried out to isolate the one protein that is desired from the thousands of other proteins produced by the microorganism. The isolated protein must be rigorously purified to eliminate contaminants from the final product. In many cases, separation and purification is the most expensive part of the production process. Courtesy, Genentech. Biochemical processes in humans can now be measured by such techniques as positron emission tomography, magnetic resonance imaging, and x-ray computer-assisted tomography, and the measurements can be enhanced by digital subtraction methods.
Research frontiers also include developing ways to simulate in vivo processes in vitro and extending the power and applicability of such simulations to allow for better prediction of the performance of biomedical materials and devices in the patient. Fundamental information on the correlation between the in vivo and in vitro responses is limited. Chemical engineers might also make contributions to the problem of noninvasive monitoring of implanted materials. IMPLICATIONS OF RESEARCH FRONTIERS The most successful efforts on problems such as those listed above will come from a new breed of chemical engineer, fluent in the language and concepts of modern biology and medicine.
Such plant cell clones are already being used to produce new crop varieties that are more resistant to adverse environmental conditions or disease. Examples include disease-resistant trees and virus-free potatoes. Cell culture techniques will continue to be used to increase crop productivity by allowing horticulturists to propagate quickly new plant strains showing • increased resistance to pests, drought, or soil salinity; • higher productivity or enhanced growth rates; • ability to produce increased amounts or higher quality of seed proteins and other plant products such as alkaloids, carotenes, latex, and steroids; and • improved efficiency of nitrogen fixation and photosynthesis.