By Alan H. B. Wu
Univ. of Connecticut, Hartford. Demonstrates the makes use of of cardiac markers in treating coronary artery sickness and their use in scientific settings. additionally discusses using natriuretic peptides for congestive center failure. Covers new info on ischemic and genetic markers. prior version: c1998. DNLM: Myocardial Infarction--diagnosis.
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It was hoped that the LMWHs might be particularly effective for prolonged therapy in patients at high risk for recurrent ischemic events. However, this has not been substantiated with a 3-mo study of twice daily dalteparin, compared with placebo (FRISC II) showing a reduction in the composite end point of death and MI at 1 mo, which was not sustained at 6-mo follow-up (52). Another study (TIMI 11B) of prolonged enoxaparin for 35 d after initial stabilization demonstrated no incremental benefit for prolonged therapy, with an increased risk of major bleeding (44).
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