Download Cardiac Dysfunction in Chronic Uremia by Philip J. Held, Nathan W. Levin, Friedrich K. Port (auth.), PDF

By Philip J. Held, Nathan W. Levin, Friedrich K. Port (auth.), Patrick S. Parfrey, John D. Harnett (eds.)

Cardiac disorder is the most important reason behind loss of life in dialysis sufferers, accounting for over one 3rd of deaths. This publication specializes in myocardial functionality and disorder in power uremia. it truly is aimed toward training and coaching nephrologists, cardiologists, and internists, and at examine employees within the box. we've attempted to supply an updated, in-depth overview of the topic through inviting specialists in scientific epidemiology, pathophysiology, and thera­ peutics to write down the 18 chapters. The ebook is split into 3 sections. the 1st part contains 5 chapters that offer an summary of the load of affliction linked to cardiac ailment in end-stage renal illness and a evaluation of scientific epidemi­ ological points of assorted cardiac illnesses that take place in renal sufferers. the second one part discusses abnormalities of left ventricular contractility and mass, and the standards that predispose to either systolic and diastolic problems. the significance of high blood pressure, anemia, hyperparathyroidism, hyper­ lipidemia, and diabetes mellitus in predisposing to those abnormalities is reviewed wonderfully through researchers energetic in those parts. the ultimate part concentrates on therapeutics. info and opinion on administration of congestive center failure, cardiomyopathy, coronary artery sickness, high blood pressure, and arrhythmias are supplied. In modifying this ebook, now we have reviewed an intensive literature, yet un­ thankfully we have now turn into extra acutely aware that colossal gaps in our knowl­ part exist. inadequate top quality medical study has been undertaken xiii xiv Preface in regards to the quite a few cardiac illnesses that ensue in end-stage renal disease.

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The risk of cardiac failure associated with left ventricular hypertrophy was comparable to that of myocardial infarction. In fact, for women, the risk of cardiac failure was twice as high in those with electrocardiographic left ventricular hypertrophy as it was in all women who survived myocardial infarction [50,51). Prognosis Once clinically manifest, cardiac failure was highly lethal. Death occurred in 82% of men and 67% of women within six years, a death rate of 4 to 5 times the general population of equivalent age [50,51].

01. 11 or number of cases is less than ten. Reproduced from Gordon T, Kannel WB [4]. ) 2. Lessons from Framingham: Cardiac disease 21 sudden, occurring within one hour of the terminal event [4]. Much of the mortality (44%) occurred in people who had no clinical evidence of coronary heart disease; two thirds of those who died suddenly had no prior evidence of disease [4]. If a person survived the initial coronary attack, he or she had a risk of subsequent death several times that of a person free of disease [4] (table 2-1).

Cardiol Clin 5(1):1. 51. McKee PA, Castelli WP, McNamara, et al. 1971. The natural history of congestive heart failure: The Framingham Study. N Engl) Med 26:1441-1446. 52. Kannel WB, Hjortland M, Castelli WP. 1974. Role of diabetes in congestive heart failure: The Framingham Study. Am) Cardiol 34:29-34. 53. Kannel WB, Sytkowski PA. 1987. Atherosclerosis risk Factors. Pharm Ther 32:225. 54. Kannel WB, Gordon T. 1978. Evaluation of cardiovascular risk in the elderly: The Framingham Study. Bull NY Acad Med 54:579.

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