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By G. Subramanian, Ganapathy Subramanian

Quick advancements in biotechnology create a requirement for useful, updated experiences written by way of and for specialists in undefined. This compact guide offers all proper updated details on very important bioseparation and bioprocessing options which are actively utilized within the biotechnology industries. The instruction manual offers an applications-orientated evaluate on - case stories and basic ideas for quality controls and characterization - distinctive instructions on constructing financial and technically possible bioseparation schemes - techniques and strategies for intracellular bioproduct free up - chromatographic and membrane downstream approaches utilized in biotechnology - purposes of recent non-invasive tools reminiscent of neural networks for online estimation and regulate of fermentation variables on an commercial scale - a realistic, commercially-relevant advisor to biosafety and lots of extra facets that are indispensible for current and destiny commercial luck.

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Sample text

For the SMB mode, as explained in this chapter, the possibility of separation relies on an adequate choice of flow rates, and consequently we can expect the SMB to be very sensitive with respect to the flow rates. In order to exemplify this behavior, let us consider the separation of the optical isomers of the threonine already presented [ 5 5 ] . In Fig. 1-16, the influence of the recycle flow rate on the extract and raffinate purities is given. It appears that both extract and raffinate are pure for a recycle flow rate of 22 mL min-' (all other flow rates being fixed).

Ci where M is the solid flow rate and i on the solid; meanwhile the flux of i moving upward with the eluent is Fu= Q . C, where Q is the liquid flow rate in the zone considered. Consequently, if: ci Bi = F, / F d < 1 the net flux of i is downward Oi = FuI > 1 the net flux of i is upward Fd A constraint is associated to each TMB zone as expressed in Table 1-2: If all the inequalities given in Table 1-2 are assumed to be satisfied through the same factor fi (0 > l), one obtains: Table 1-2. Constraints to be fulfilled by the internal TMB flow rates in order to ensure a separation between two products A and B (B more retained than A).

2 . 0 1 h-l. At this point, all flow rates are known. The estimation of column length and diameter requires the required number of plates and pressure drop, to be taken into account. 6 Main Applications and Developments 25 Regarding the number of plates, we will only consider the sugar (limiting species). 12 . 538 s. 10T4 + 3 . 5 4 . ~ ~ AP The experimental pressure drop allows us to write: - = 1887 . urnbar I m L The separation being a medium difficult separations, we can guess that 200 plates are enough [9] for performing the work (this could be confirmed with numerical simulation).

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