By B. Singer, H. Fraenkel-Conrat (auth.), Roland F. Beers Jr., Werner Braun (eds.)
In fresh years our horizons in regards to the position of nucleic acids in organic structures were increased drastically via the discovering that those molecules not just hold and transmit particular infOImation but additionally can act as much less particular triggers of antiviral components and of immunological responses. The latter homes are of specific curiosity when it comes to attainable usage in human and veterinary medication and as a result led, within the previous few years, to the improvement of a brand new learn zone that mixes either primary and utilized difficulties in a uniquely beautiful manner. moreover, the significance and the complexity of the issues has attracted investigators from many fields, together with molecular biologists, virologists, immunologists, chemists, biophysicists, oncologists, pharmacologists, and clinicians. A dialogue of recent advancements during this sector of organic results of polynucleotides, with specific emphasis on interferon induction and amendment of immune responses, for that reason, appeared a logical subject for one of many annual symposia that Miles Laboratories, Inc. , has backed lately. The deal with ment of Miles permitted the recommendation with enthusiasm and therefore once more earned the gratitude of the clinical neighborhood for sponsoring a catalytic assembly that used to be largely serious about easy study difficulties and merely tangentially with speedy functions. Springer-Verlag agreed to post the complaints of the assembly which was once held on the Americana lodge in ny urban, June 4-5, 1970 and attracted an strangely huge audience.
Read or Download Biological Effects of Polynucleotides: Proceedings of the Symposium on Molecular Biology, Held in New York, June 4–5, 1970 Sponsored by Miles Laboratories, Inc. PDF
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Extra info for Biological Effects of Polynucleotides: Proceedings of the Symposium on Molecular Biology, Held in New York, June 4–5, 1970 Sponsored by Miles Laboratories, Inc.
H. FRAENKEL-CONRAT: I would like to make a couple of comments about the first two papers. First of all, in response to Dr. Beers'initial question, I think that it is template activity that is being measured rather than initiation, because in all cases where we have done a nearest-neighbor analysis it has come out properly. The second thing I would like to add is that I think there is a little pro blem about the specificity of the misincorporation which is induced by the alkylation of cytidine. I think both our groups have shown that UTP and ATP can be introduced by alkylation.
R. (1967a). Inducers of interferon and host resistance. IV. Double-stranded replicative form RNA (MS2-RF-RNA) from E. coli infected with MS2 coliphage. Proc. Natl. Acad. Sci. 58: 2102. Field, A. , Tytell, A. , Lampson, G. , and Hilleman, M. R. (1967b). Inducers of interferon and host resistance. II. Multistranded synthetic polynucleotide complexes. Proc. Natl. Acad. Sci. 58, 1004. - - - (1968). Inducers of interferon and host resistance. V. In vitro studies. Proc. Natl. Acad. Sci 61: 340. Finter, N.
LOOllg of poly I . p. 1 time per 2 days (every other day). C Treatment was begun on day indicated for each group and continued until the tenth day after infection. a b 52 s. Baron et al. weekly beginning on the second day. p. v. p. dosage are presented in Figure 3. It may be seen that hypo reactivity following the initial dose of 200 Ilg poly I· poly C was most marked with daily doses, less marked with doses given three times a week, and not evident with doses given once weekly. The degree and duration of hypo reactivity were determined by the interferon response to subsequent doses of poly I· poly C, given at various time intervals after an initial dose.