By W.P. Kaschka, D. Rujescu, W.F. Gattaz
Suicide is among the most crucial reasons of demise in sleek societies. To advance more advantageous preventive measures, we need to pay attention to and study extra approximately its neurobiological foundations. in recent times, the instruments of recent neurosciences have more and more been applied to represent the pathophysiology of advanced human behaviors resembling suicide. to enhance suicide chance overview and suicide prevention, a greater realizing of its pathophysiology is important. This contains examine from a number of disciplines corresponding to neuropsychological, psychosocial and cultural reports but additionally findings from biochemistry, neuropathology, electrophysiology, immunology, neuroimaging, genetics, and epigenetics. vital effects have, for instance, been received within the box of gene-environment interplay and suicidal habit. we've got simply began to appreciate how early-life adversity may well elevate suicide probability by way of epigenetic mechanisms. in keeping with such insights, novel healing interventions and preventive measures will be constructed. moreover, a greater figuring out of the pathophysiological mechanisms desirous about suicidal habit may possibly display the mechanism of compounds like lithium salts. during this ebook, suicidal habit and its prevention is mentioned through overseas specialists within the gentle of the latest effects from a extensive spectrum of neurosciences.
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Extra resources for Biological Aspects of Suicidal Behavior
53 Cowburn RF, Marcusson JO, Eriksson A, Wiehager B, O’Neill C: Adenylyl cyclase activity and G-protein subunit levels in postmortem frontal cortex of suicide victims. Brain Res 1994; 633;297–304. 54 Pacheco MA, Stockmeier C, Meltzer HY, Overholser JC, Dilley GE, Jope RS: Alterations in phosphoinositide signaling and G-protein levels in depressed suicide brain. Brain Res 1996; 723: 37–45. 55 Gurguis GN, Turkka J, Laruelle M, Kleinman J, Linnoila M: Coupling efficiency of brain β-adrenergic receptors to Gs protein in suicide, alcoholism and control subjects.
Researchers who found an increase in 5-HT2A receptors used spiperone and ketanserin, as well as LSD; therefore, these inconsistencies cannot be attributed to the difference in the ligands used for these studies. Differences in age, sex and axis I diagnosis may explain some of the discrepancies. In addition to radioligand binding, we examined the protein and mRNA expression of 5-HT2A receptors in Brodmann’s area 9, the hippocampus and nucleus accumbens of teenage suicide victims . We observed a significant increase in 125I-LSD binding in the PFC of suicide victims.
BDNF in Suicide BDNF is a critical gene regulated by both PKA and PKC and participates in a wide range of physiological functions, including neurite outgrowth, phenotypic maturation, morphological plasticity, and synthesis of proteins for differentiated functioning of neurons and synapses. Our group was the first to examine the role of BDNF in suicide . In this study, we found that the expression of BDNF was significantly lower in both the PFC and hippocampus of suicide subjects regardless of the psychiatric diagnosis.