By R. M. Dougherty (auth.), G. F. De Boer (eds.)
The goal of the sequence advancements in Veterinary Virology is to supply monographs facing the key animal viral ailments. every one quantity will comprise the newest achievements in basic study and sensible purposes and will be readable for individuals from numerous disciplines and varied backgrounds. The multi-author method offers the easiest chance to maintain each one bankruptcy on the maximum point and makes the composition of the volumes doable to the editors. This monograph on Avian Leukosis offers finished reports at the contemporary historical past of avian retrovirus examine, on epizootiological, virological, pathological points, on tumor induction, the immune reaction to avian unfashionable viruses, virus-cell interactions and on strategies for prognosis. the quantity offers in most cases with exogenous avian leukosis virus (ALV) infections, yet one bankruptcy is solely dedicated to endogenous avian leukemia virus. Molecular biology elements are restricted to numerous oncogenes and to lymphoma induction in view that retroviruses, together with these particular for avian species, have lately been defined intimately within the chilly Spring Harbor Laboratory sequence "Molecular Biology of Tumor Viruses". chapters are dedicated to the sensible software of insights got from avian leukosis learn: impacts of AL V an infection on construction functionality and eradication procedures.
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This thought was strengthened by the isolation of AEV-H which has very similar properties to AEV-ES4 but lacks the erbA sequence (5). Howe\er, matters are not so clear-cut since the presence of erbA renders AEV-ES4 more tumorigenic in \ivo, implying that erbA plays some role in the development of the malignant phenotype, especially erythroblastosis (3). AEV-ES4 IRNA genome I 5' 3' L~____LI\~~ga~gL-~__~e~rb~A~__~e~rb~B~____L~AAAAN Protein products: • p75 gag-erbA •• p 625 gp66 translation product • • + gp68 gp74 intracellular mermbranes intracellular membranes e r b B plasma membrane Activities: gp68 and gp74 have associated tyrosine kinase activity IRNA genome I AEV-H 5' n Protein products: • Pr76 gag + + gp72 erbB r1 AAAAN p67 plasma membrane Activities: gp72 has an associated tyrosine kinase activity Figure 1_ Genome structure and protein products of erb-containing viruses, causing erythroblastosis.
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