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By Richard M. Lambrecht and Nabil Morcos (Eds.)

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And Pitts, J. , Envir. Sei. Tech. 12, 954 (1978). 11. , Arch. Environ. Health 30, 453 (1975). 12. Rodkey, F. , Clin. Chem. 22, 1986 (1976). 13. , Fd. Cosmet. Toxicol. 9, 219 (1971). 14. Freeh, J. , February, 1975. 15. Shy, C. , February, 1975. 16. Fine, D. , Rounbehler, D. , Belcher, N. , and Epstein, S. , Science 192, 1328 (1976). 17. Rounbehler, D. , Fine, D. , Igbal, Z. , and Epstein, S. , Science 197, 917 (1977). 18. Newberne, P. , Science, 204 1079 (1979). 19. Johnson, E. , Harkey, A. , Blehm, D.

2Ό 388 (1978). 76. Meeks, J. , "Symposium on Recent Developments in Biological and Chemical Research With Short-Lived Radioisotopes," Abstract No. 24, Division of Nuclear Chemistry and Technology, 178th American Chemical Society National Meeting, Washington, D. , September 10-14, 1979. 77. Thayer, J. R. and Huffaker, R. , "Symposium on Recent Developments in Biological and Chemical Research with Short-Lived Radioisotopes," Abstract No. 26, Division of Nuclear Chemistry and Technology, 178th American Chemical Society National Meeting, Washington, D.

Later *°F was removed with a neutral alumina column. Chemical identification was performed with a high performance liquid Chromatograph system fitted with radiation uv-absorbance and uv-fluorescence detectors (Fig. 7). The importance of rapid radiochromatographic procedures, on-line analysis of separations, and the capability for acquiring large amounts of data in a readily retrievable form cannot be overemphasized if efficient use of costly or scarce cyclotron time is a prerequisite. These capabilities are important for rapid radiochemical and chemical purity assessment of the short-lived labeled compounds prior to biological experiments; rapid analysis of multiple samples from the same animal, thus obviating statistically confounding "biological variability" between animal and decision-making about optimizing protocols of "inprogress" experiments.

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