By Eleazar Shafrir, Anders A F Sima
Animal types of Diabetes: A Primer introduces features of the main primary animal species with numerous diabetic syndromes which were constructed and broadly investigated over the past few many years. It contains animal versions which are available, good defined and confirmed to be of price within the learn of either forms of diabetes. generally referenced, this e-book might be of worth to new and tested investigators, graduate scholars and pharmaceutical scientists engaged on the advance of antidiabetic and preventative modalities in quite a few components of diabetes and its problems.
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Extra info for Animal Models in Diabetes: A Primer (Frontiers in Animal Diabetes Research)
And Goldschneider, I. (1993) Recent thymic emigrants in the rat express a unique antigenic phenotype and undergo post-thymic maturation in peripheral lymphoid tissues. J. , Chan, E. A. (1994) Glipizide-induced prevention of diabetes and autoimmune events in the BB rat. J. , 7, 753–761. , Dybdal, N. A. (1994) Islet expression of interferon-α precedes diabetes in both the BB rat and streptozotocin-treated mice. Immunity, 1, 469– 476. A. L. (1998) High frequency apoptosis of recent thymic emigrants in the liver of lymphopenic diabetes prone BioBreeding rats.
1992). , 1998). MORDES ET AL. 23 Animal Models of Induced Type 1 Diabetes It can be argued that analyses of induced IDDM in diabetes resistant BB rats are of limited relevance because of their dependence on perturbation with viral infection, poly I: C, or depletion of RT6+ regulatory cells. Perturbants, however, do not generate autoreactivity. They only facilitate its expression and detection. g. WF rats, that do not have the genetic predisposition of the BB rat (see below) (Ellerman and Like, 1998).
It cannot be overemphasized that extrapolation from rodent to human can be misleading. The 26 AUTOIMMUNE DIABETES MELLITUS IN THE BB RAT Table 3 Experimental in nmunotherapies for autoimmunity in BB rats Selective immunosuppression with monoclonal antibodies Cytokine therapy Immunostimulation High dose Poly I: C Low dose Poly I: C CFA BCG Ciamexone Peptide immunization Miscellaneous Parenteral Nicotinamide Oral Nicotinamide Parenteral insulin Oral insulin Vitamins Androgen NO inhibitors DP-BB Rat Induced DR-BB rat diabetes Prevention by antibodies against CD8, CD2, ASGM1, CD3 Prevention by TNF-α, lymphotoxin, INFγ, IFNα, Prevention by anti-CD8 Accelerates onset Prevents diabetes Prevents disease Prevents diabetes Probably ineffective GAD, HSP65 ineffective Induces diabetes Induces diabetes Unknown Unknown Unknown Unknown Does not prevent diabetes May reduce frequency Prevents IDDM at doses that cause hypoglycemia Ineffective Unknown Does not prevent diabetes Delay onset Unknown Unknown Same as DP Unknown Ineffective Unknown Unknown Unknown Partial listing of immunotherapeutics assayed in the BB rat.