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By Professor J. R. Trounce (auth.), Professor J. R. Trounce (eds.)

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Clin. pharmac. Ther. (1964), 5, 322. Hanlon, T. E. , Psychopharmacologia (1965),7, 89. Trethowan, W. , (editor) Proceedings of a Psychiatric Symposium on Haloperidol. Clin. Trials]. (1965),2, 133. 55 A Guide to Drugs in Current Use 23. , Acta Psychiat. scand. (1964), 40, 65. 24. Wittenborn, J. , The Clinical Psychopharmacology oj Anxiety (1966), Thomas Springfield, Illinois. 25. McNair, D. M. , Psychopharmacologia (1965), 7, 256. 26. Boyer, P. , Dis. Nerv. Syst. (1966), 27, 35. 27. , Physical Methods oj Treatment in Psychiatry (1963), Livingstone, Edinburgh.

These drugs are widely distributed following absorption, but there appears to be little correllation between brain concentrations and clinical effects. These may be divided into peripheral actions, including stimulation of muscle and vasoconstriction, and central 54 Psychotropic Drugs actions such as stimulation of sympathetic centres with tachycardia, hypertension, hyperglycaemia, pilo-erection and eye ball protrusion. Metabolism varies, with dephosphorylation, deamination and hydroxylation; piperidyl benzylate being rapidly excreted unchanged in the urine.

Subcutaneous morphine. 30 The Analgesics THE MINOR ANALGESICS AND ANTI-INFLAMMATORY AGENTS Nearly all share analgesic, anti-pyretic and anti-rheumatic (antiinflammatory) properties. These drugs are free of addiction potential, although patients can become habituated to their use. Their exact site of action is still not entirely clear. Vasodilation, whether produced centrally or peripherally, causes much of the antipyretic activity. The analgesia may originate centrally or may be due to a direct effect on pain receptors.

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